Cisplatin pulmonary toxicity

Author: eukl

August undefined, 2024

WebSep 1, 2024 · Cisplatin for injectioncan cause dose-related nephrotoxicity, including acute renal failure that becomes more prolonged and severe with repeated courses of the drug. … WebBased on 4448 patients, the incidences of dyspnea and other serious pulmonary toxicity were 0.45% and 0.27% respectively. Based on an estimated 217 400 patients treated with commercial gemcitabine worldwide, the crude incidences of dyspnea and other serious pulmonary toxicity were 0.02% and 0.06% respectively.

Prognostic impact of bleomycin pulmonary toxicity on the

WebNov 26, 2024 · Cisplatin-Induced Toxicity . Cisplatin, cis- diamine-dichloro-platinum (CDDP) is one of the most used chemotherapy drugs because it is effective against different types of tumors. ... Mediators such as 4-HNE and H 2 O 2 are among the most relevant secondary messengers induced by ozone during lung toxicity following airway … WebJan 12, 2024 · Cisplatin has severe nonhematological toxicities, particularly nephrotoxicity and gastrointestinal toxicity. The recent development of new antiemetic therapies has greatly reduced... granite city yearbooks online

Review on Pharmacology of Cisplatin: Clinical Use, …

WebFeb 2, 2024 · Cisplatin can cause not only nephrotoxicity but also cause severe neurotoxicity, which significantly limits its clinical use. A study showed that a continuous high dose of cisplatin stimulation disrupted the blood-brain barrier, leading to brain cell edema and neuronal necrosis (Namikawa et al., 2000). Regarding the study of prevention and ... WebRenal toxicity is a prominent component of the toxicity profile of platinum-based chemotherapy. Kidney damage, once dose limiting for cisplatin, occurs in some patients who receive carboplatin and may occur with the third-generation platinum analog ormaplatin. Webprimary pulmonary toxicity of cisplatin in cats. (Journal of Veterinary Internal Medicine. 1987; 129-35) CISPLATIN (cis-diamminedichloroplatinum) is a widely used … granite city yarmouth countertops

Clinical comparative investigation of efficacy and toxicity of ...

Oral vinorelbine and cisplatin with concurrent radiotherapy after ...

WebPulmonary toxicity of cytotoxic agents Platinum compounds The administration of cisplatin and carboplatin, the 2 most commonly used platinum derivative agents, can … WebMay 9, 2024 · A general discussion of the clinical presentation, pathogenesis, diagnosis, differential diagnosis, and management of antineoplastic agent-induced pulmonary toxicity is covered elsewhere, as is lung toxicity associated with molecularly targeted … granite clay potWebIn group 1, cisplatin was administered at a dose of 60 mg/m2 to four cats. In an attempt to avoid renal toxicity, saline diuresis was induced by administering 0.9% saline solution … chink of light meaning

"WebToxicity is progressive, occurring over the course of weeks to months. The most strongly associated predictor of neurotoxicity is dose and cases occur with doses approaching 40 mg/m2. Diagnosis... " - Cisplatin pulmonary toxicity

Cisplatin pulmonary toxicity

Pathophysiology of cisplatin-induced acute kidney injury

WebSep 4, 2013 · The short hydration is safe without severe renal toxicities in regimens containing cisplatin (≥75 mg/m 2) for patients with lung cancer. short hydration, magnesium supplementation, cisplatin, lung cancer, renal toxicity Topic: chemotherapy regimen cisplatin creatinine kidney failure mannitol safety kidney lung cancer pemetrexed toxic … WebTUBULAR TOXICITY Platinum compounds Cisplatin(cis-dichlorodiammineplatinum)–platinum coordination complex is an effective chemotherapy against a wide spectrum of tumors such as testicular, head and neck, ovarian, lung, cervical, and bladder cancers. Nephrotoxicity is the dose-limiting toxicity of cisplatin. …

Did you know?

WebJan 16, 2024 · Advise the patient to call 911 immediately if they develop any signs of infection (immunosuppression), experience coughing, wheezing, or shortness of breath (pulmonary toxicity), or notice unusual bleeding (liver or bone marrow suppression). WebSep 6, 2024 · Radiation pneumonitis (RP) and radiation fibrosis (RF) are two dose-limiting toxicities of radiotherapy (RT), especially for lung, and esophageal cancer. It occurs in 5–20% of patients and limits the maximum dose that can be delivered, reducing tumor control probability (TCP) and may lead to dyspnea, lung fibrosis, and impaired quality of …

WebPulmonary toxicity is one of the most serious adverse effects associated with a quick course of vincristine, bleomycin, and cisplatin neoadjuvant chemotherapy (NAC-VBP). The aim of this study was to evaluate pulmonary toxicity related to a quick course NAC-VBP. WebJul 22, 2024 · Cisplatin is a potent and valuable chemotherapy agent used to treat a broad spectrum of malignancies. Renal tubular dysfunction and a cumulative impairment in …

WebOct 7, 2024 · Depending on a dose (single or cumulative) cisplatin can cause leucocytopenia, thrombocytopenia, and anemia also in mice (toxicity on hemopoietic cells, Figure 1 ). Myelotoxicity can be observed already a day after cisplatin administration and is more toxic for earlier hemopoietic progenitor cells than for the mature cells [ 74 ]. WebSep 15, 2024 · Common side effects include nausea, vomiting, bone marrow suppression, electrolyte imbalance, neuropathy, ototoxicity and nephrotoxicity. Cisplatin is mutagenic, …

WebClinical Comparative Investigation of Efficacy and Toxicity of Cisplatin plus Clinical comparative investigation of efficacy and toxicity of cisplatin plus gemcitabine or plus Abraxane as first-line chemotherapy for stage III/IV non-small-cell lung cancer Dan Ai,1,2 Yan Guan,2 Xiu-Ju Liu,2 Chu-Feng Zhang,1,2 Peng Wang,1,2 Hong-Lu Liang,1,2 Qi …

WebCisplatin, a platinum analogue, is an alkylating agent used in combination with other agents to treat a variety of solid malignancies, including lung cancer, head and neck cancer, mesothelioma, ovarian cancer, and bladder cancer. It is also used prior to bone marrow and stem cell transplantation. granite city zillowWebPubMed Central (PMC) chink of lightWebJan 23, 2024 · Pulmonary toxicity due to bleomycin is one of the most common, severe and extensively studied chemotherapy complications. The major toxicities occur in the … chink of knives meaningWebAug 1, 1998 · Cisplatin doses were fixed and were not reduced for any toxicity. The most common reasons for irinotecan dose reduction were nausea and vomiting (27% of patients), followed by diarrhea (21%), and neutropenia (12%). Response and Survival All patients were evaluated for response and survival. chin kok foongWebMyelosuppression is the most common toxicity of gemcitabine therapy. Pulmonary toxicities due to gemcitabine have, however, been reported. Dyspnea occurs in approximately 25% of patients treated with gemcitabine, whereas serious pulmonary toxicities are much less common, approximately 0.3%. chin kof 2002WebCisplatin is a potent and valuable chemotherapy agent used to treat a broad spectrum of malignancies. Renal tubular dysfunction and a cumulative impairment in kidney function, as manifested by a decline in the glomerular filtration rate (GFR), can be dose limiting. chink of armourWebFeb 14, 2008 · Cisplatin is a platinum chemotherapeutic used in a variety of malignancies. The antineoplastic activity occurs from DNA cross-links and adducts, in addition to the … chink monkey