Cyp17a1是什么
WebBackground. CYP17A1, also known as cytochrome P450C17, is a steroidogenic enzyme belonging to the P450 cytochrome superfamily of monooxygenases (1, 2). In humans, CYP17A1 expression is abundantly expressed in the adrenal cortex, where it plays a central role in the androgen synthesis pathway (2). CYP17A1 is the primary target of …
Cyp17a1是什么
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WebCYP17A1. (cytochrome P450 family 17 subfamily A member 1). 该基因编码细胞色素p450酶超家族的一个成员。. 细胞色素p450蛋白是一种单加氧酶,催化药物代谢和胆固 … WebMay 5, 2011 · 2013-11-15 白血病发生与什么基因有关 2024-02-15 基因检测出风险,还能投保么 2015-07-24 肝细胞基因点位检测是什么 2014-04-27 什么是荷尔蒙? 2014-05-01 …
WebMay 15, 2024 · Cytochrome P450 17A1 (CYP17A1) is a critical steroidogenic enzyme, essential for producing glucocorticoids and sex hormones. This review discusses the complex activity of CYP17A1, looking at its role in both the classical and backdoor steroidogenic pathways and the complex chemistry it carries out to perform both a … WebDec 14, 2015 · The excessive production of androgen, which effectively fuels the progression of cancer, especially prostate cancer, was first treated by surgical methods (), whereas more modern approaches are focused on the discovery and development of pharmaceuticals that can selectively inhibit androgen synthesis (2, 3).A member of the …
WebCYP17A1 is strongly expressed in half about of human prostate carcinomas, implying an intracellular androgen synthesis by cancer cells. Abiraterone effectively blocked nuclear … WebCYP17A1 是阿比特龙的主要靶标,阿比特龙是一种用于治疗去势抗性前列腺癌 (CRPC) 的合成类固醇 (3, 4)。. 阿比特龙可转化为更具活性的 D4A,D4A 通过抑制 CYP17A1 和其他类固醇激素合成酶来抑制雄激素受体信号转导 (3, 4)。. 这能抑制 5α-双氢睾酮 (DHT) 合成,DHT …
WebFunctional analysis using a yeast microsomal assay with coexpression of human CYP17A1 or CYP21A2 with wild-type or mutant human POR revealed equivalent decreases in CYP17A1 and CYP21A2 activities by Y181D, H628P, and S244C. In contrast, A287P had a differential inhibitory effect, with decreased catalytic efficiency (Vmax/Km) for CYP17A1 ...
WebMar 21, 2024 · CYP17A1 (Cytochrome P450 Family 17 Subfamily A Member 1) is a Protein Coding gene. Diseases associated with CYP17A1 include Adrenal Hyperplasia, Congenital, Due To 17-Alpha-Hydroxylase … linking two computers togetherWebJun 11, 2024 · The cytochrome P450 family 17 subfamily A member 1 (CYP17A1) gene, located on chromosome 10q24.3, consists of eight exons and seven introns and is expressed mainly in the adrenal glands and gonads ( 6, 7 ). In humans, CYP17A1 encodes the P450c17 protein, a key enzyme in the steroidogenic pathway. It can catalyze two … linking two computershttp://zfish.ihb.ac.cn/Article/4752.html houlton band of maliseet indians logoWebDec 7, 2024 · Progesterone-17α-hydroxylase (CYP17A) could transform progesterone to 17α-hydroxyprogesterone (17-HP). The main limitation of 17-HP biological production is the lack of CYP17A or the low activity of existing enzymes. A novel CYP17A1 (BT_CYP17A1) from Bovine taurus was identified by genome mining and heterolo houlton bandWebCYP17A1, also known as cytochrome P450C17, is a steroidogenic enzyme belonging to the P450 cytochrome superfamily of monooxygenases (1, 2). In humans, CYP17A1 … houlton band of maliseets officeWebFunction. A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis ( PubMed: 9452426, PubMed: 27339894, PubMed: 22266943, PubMed: … linking two computers wirelessWebCYP11A1 (D8F4F) Rabbit mAb. #14217. 使用 CYP11A1 (D8F4F) Rabbit mAb(绿色)对 NCI-H295R(左,阳性)和 SW-13(右,阴性)细胞进行共聚焦免疫荧光分析。. 肌动蛋白丝用 DyLight ® 554 Phalloidin #13054(红色)标记。. 蓝色伪彩 = DRAQ5 ® #4084(DNA 荧光染料)。. 使用 CYP11A1 (D8F4F) Rabbit mAb ... linking two computers on a network