WebSolvent-free intermolecular and intramolecular Thorpe reactions proceeded efficiently to give acyclic and cyclic enamines, respectively. In the latter case, the reaction products were obtained as colorless crystalline powders just by washing of the reaction mixture with … WebA Thorpe condensation is the key bond construction in a rapid and efficient synthesis of substituted cytosine derivatives from readily available starting materials. [reaction: see text] A Thorpe condensation is the key bond construction in a rapid and efficient synthesis of substituted cytosine derivatives from readily available starting materials.

solvent‐free synthesis - ResearchGate

WebOct 16, 2009 · A highly efficient (93% overall yield) and enantioselective (94% ee) synthesis of the Wieland–Miescher ketone (10-g scale) through a solvent-free Robinson annulation … WebJan 30, 2024 · The application of HHP enables achieving of a truly green process, that is catalyst and solvent-free (except when NH 4 OH was used), occurs in seconds at room temperature with quantitative yields thus no purification is necessary and the only byproduct is non toxic water. * Exclusive of taxes This article contains 6 page (s) Log in knot tying materials

Highly Efficient Michael Addition Reaction of Amines …

WebA solvent-free reaction has been reported involving grinding liquid 2-chlorobenzaldehyde with potassium hydroxide in a mortar and pestle: [7] Variations [ edit] In the Tishchenko reaction, the base used is an alkoxide rather than hydroxide, and the product is an ester rather than the separate alcohol and carboxylate groups. WebThe present solvent-free and catalyst-free procedure provides a powerful and versatile acylation method for alcohols, thiols, amines and oximes. This method is endowed with several unique merits, namely, simplicity in operation, mild reaction conditions tolerable to acid sensitive functionalities, wide applicability and cost-efficiency. WebIn organic chemistry, the Buchwald–Hartwig amination is a chemical reaction for the synthesis of carbon–nitrogen bonds via the palladium-catalyzed coupling reactions of amines with aryl halides. Although Pd-catalyzed C-N couplings were reported as early as 1983, Stephen L. Buchwald and John F. Hartwig have been credited, whose publications … red fur cape coat